gepirone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anxiolytics, buspirone derivatives | 4562 | 83928-76-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06AX19 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
| MeSH PA | D014151 | Anti-Anxiety Agents |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D018490 | Serotonin Agents |
| MeSH PA | D017366 | Serotonin Receptor Agonists |
| MeSH PA | D014149 | Tranquilizing Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Major depressive disorder | indication | 370143000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.51 | Basic |
| pKa2 | 2.23 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | GPCR | Ki | 7.24 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | AGONIST | Ki | 7.89 | CHEMBL | ||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.44 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 7.50 | CHEMBL | |||||
| Serotonin 1 (5-HT1) receptor | GPCR | IC50 | 6.17 | CHEMBL | |||||
| Adrenergic receptor alpha-1 | GPCR | Ki | 5.62 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:135990 | CHEBI |
| CHEMBL284092 | ChEMBL_ID |
| C039979 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5676 | INN_ID |
| 83928-66-9 | SECONDARY_CAS_RN |
| DB12184 | DRUGBANK_ID |
| JW5Y7B8Z18 | UNII |
| C0066624 | UMLSCUI |
| CHEMBL1204187 | ChEMBL_ID |
| 55191 | PUBCHEM_CID |
Pharmaceutical products:
None